
64.8% (95% CI 64.6-65.0), varying from 73.8% among patients aged 65-69 to 45.8% among
patients aged 80 and older.
ii) Induction medications and dosing are both attributable and modifiable
(1) Among 320,585 total patients, 22.6% experienced the outcome of pre-incision severe
hypotension (MAP≤55mmHg).
(2) 20.7% with non-invasive blood pressure measurements
(3) 35.0% with invasive blood pressure measurements had the outcome.
(4) Propofol induction dose (considered both as a continuous variable and as yes/no
>1.5mg/kg) was associated with pre-incision hypotension (MAP<55mmHg)
(5) However, a multitude of other factors both captured and not captured within MPOG
may mediate this relationship.
c) Percent of patients age >65 without preoperative hypotension undergoing GA who had an
episode of MAP<55mmHg within 15 minutes of induction and prior to surgical incision. (see slide
deck)
d) Percentage of cases where severe hypotension during anesthesia induction (defined as MAP <
55 mmHg) was avoided
e) Measure Time Period: Induction Start through Surgery Start
f) Inclusions: All patients requiring general anesthesia
g) Exclusions:
i) Patients <18 years old
ii) ASA 6 cases/ Organ Harvest
iii) Baseline MAP <60 mmHG
iv) Labor Epidurals / Obstetric Non-Operative Procedures
v) Anesthesia Procedures
h) Success Criteria: MAP > 55 mmHG throughout induction time period
i) Discussion:
i) Jing Tao (Memorial Sloan Kettering): Data shows that MAP<65mmHg is the cutoff associated
with bad outcomes. Is this threshold set too low for this measure? Also, it’s sustained low
MAP that is associated with bad outcomes not a single instance of low MAP.
(1) Rob Schonberger (Yale): Cleveland Clinic found in their dataset that one minute of low
MAP<55 was associated with bad outcomes. Though the threshold could be modified
ii) Eric Davies (Henry Ford Allegiance): Will this measure be reported differently? Perhaps
reported as AUC with mean and standard deviation.
(1) Nirav Shah (MPOG Coordinating Center): Great point! The new dashboard now allows us
to show different visualizations in addition to pass/flag results. Will check back with the
programmer team to see if this is possible for this new measure.
iii) Mike Mathis (MPOG Coordinating Center/Michigan Medicine): Most of our references are
observational studies, less evidence around treating this hypotension and the result in terms
of outcomes. Good focus area for researchers moving forward.
iv) Shafeena Nurani (Beaumont Troy): Is there any evidence that the outcomes are different
than the BP 03 measure?
(1) Rob Schonberger (Yale): This measure specifically focuses on attribution during the
induction time period and we should definitely consider a countermeasure to avoid
hypertension, which also is not associated with better outcomes.
v) Karen Domino (U. Washington): Induction time period can vary between case types - could